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przeżywanie w wakuoli
ucieczka od odpowiedzi komórkowej
wielolekooporny
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Abstrakt
Acinetobacter baumannii to notoryczny patogen oportunistyczny, znany ze swojej zdolności do wywoływania ciężkich infekcji, szczególnie u osób z obniżoną odpornością. Częstość występowania zakażeń wielolekoopornych A. baumannii rośnie w zastraszającym tempie. Chociaż tradycyjnie uważa się go za patogen zewnątrzkomórkowy, nowe odkrycia sugerują, że A. baumannii może przetrwać i replikować się w komórkach gospodarza, unikając w ten sposób odpowiedzi immunologicznej i leczenia przeciwdrobnoustrojowego. W tym artykule dokonano przeglądu ostatnich przypadków przetrwania wewnątrzkomórkowego i zbadano strategie przetrwania stosowane przez A. baumannii, w tym jego interakcje z maszynerią komórkową gospodarza i unikanie mechanizmów obronnych gospodarza. Zrozumienie tych mechanizmów ma kluczowe znaczenie dla opracowania leków celowanych, zwalczających zakażenia A. baumannii.
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