Keywords
Spontanous preganncy
Contraception
How to Cite
Abstract
Diagnosis of menopause in women is usually related to infertility. We reported the case of a 49-year-old woman treated with menopausal hormone therapy (MHT) who spontaneously conceived. The pregnancy terminated in an early miscarriage. Patients should be informed about the risk of a pregnancy during the first year of MHT, as also contraception should be considered, especially in perimenopausal women
References
Laufer B, Simon A, Samueloff A, et al. Successful spontaneous pregnancies in women older than 45 years. Fertil Steril 2004; 81:5:1328-1332. DOI:10.1016/j.fertnstert.2003.09.056.
Rocznik Demograficzny 2023. Demographic Yearbook of Poland 2023.
ACOG and ASRM. Age-related fertility decline: a committee opinion. Fertil Steril 2008; 90(3):486-7. DOI:10.1016/j.fertnstert.2008.08.006.
Grandi G, Di Vinci P, Sgandurra A, Feliciello L, Monari F, Facchinetti F. Contraception During Perimenopause: Practical Giudance Int J Womens Health 2022; 14:913-929. DOI:10.2147/ijwh.s288070.
Godfrey EM, Zapata LB, Cox CM, et al. Unintended pregnancy risk and contraceptive use among women 45-50 years old: Massachusetts, 2006, 2008, and 2010. AJOG 2016; 214:712-718. DOI:10.1016/j.ajog.2015.12.006.
Glick I, Kadish E, Rottenstreich M. Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby Int J Womens Health 2021; 13:751-759. DOI:10.2147/IJWH.S283216.
Pawelczyk L, Sokalska A, Serdyńska M. Fertility in women in premenopausal age. Menopause Rev 2003; 1:14-18.
Petersen KB. Individual fertility assessment and counselling in women of reproductive age. Dan Med J 2016; 63(10):B5292.
Korabel J, Krzysiek J. Assessment of the ovarian reserve in a group of perimenopausal women. Menopause Rev 2013; 17(4):333-338. DOI:10.5114/pm.2013.37851.
Pethő B, Mátrai A, Agócs G, Sándor Veres D, Harnos D, Váncsa S, Bánhidy F, Hegyi P, Ács N. Maternal age is highly associated with non-chromosomal congenital anomalies: Analysis of a population-based case-control database 2023; 130(10):1217-1225. DOI:10.1111/1471-0528.17461.
Forman EJ, Treff NR, Scott RT. Fertility after 45: From natural conception to Assisted Reproductive Technology and beyond. Maturitas 2011; 70:216-221. DOI:10.1016/j.maturitas.2011.07.003.
Hamish W, Wallace B, Kelsey TW. Human Ovarian reserve from Conception to the Menopause; PloS One 2010; 27:5(1):8772. DOI: 10.1371/journal.pone.0008772.
Casper RF, Barbieri RL, Crowley WF, et al. Clinical manifestation and diagnosis of menopause. UpToDate 2021; 03.
Burger HG, Hale GE, Dennerstein L, et al. Cycle and hormone changes during perimenopause: the key role pf ovarian function. Menopuase 2008; 15(4):603-5. DOI:10.1097/gme.0b013e318174ea4d.
Broer SL, Eijkemans MJC, Scheffer GJ, et al. Anti-Mullerian Hormone Predicts Menopause: A Long- Term Follow- Up Study in Normoovulatory Women. JCEM 2011; 96(8):2532-9 DOI:10.1210/jc.2010-2776.
Martin KA, Barbieri RL. Treatment of menopausal symptoms with hormone therapy. Uptodate 2021; 03.
Laufer N, Simon A, Samueloff A, Yaffe H, Milwidsky A, Gielchinsky Y, Successful spontaneous pregnancies in women older than 45 years. Fertil Steril 2004; 81(5):1328-32.
Akbari Asbagh F, Ebrahimi A. A case report of spontaneous pregnancy during hormonal replacement therapy for premature ovarian failure Iran J Reprod Med 2011; 9(1):47-49.
Calik-Ksepka A, Grymowicz M, Bronkiewicz W, Urban A, Mierzejewski K, Rudnicka E, Smolarczyk R. Spontaneous pregnancy in a patient with premature ovarian insufficiency – case report. Menopause Rev 2018; 17(3):139-140.
Seungdamrong A, Weiss G. Ovulation in a postmenopausal woman. Fertil Steril 2007; 88:5:1438-9. DOI:10.1016/j.fertnstert.2006.11.152.
Check JH, Check ML, Katsoff D. Three pregnancies despite elevated serum FSH and advanced age. Hum Reprod 2000; 15:8:1709-1712. DOI:10.1093/humrep/15.8.1709.
Pinelli S, Artini GP, Basile S, et al. Oestrogen treatment in infertile women with premature ovarian insufficiency in transitional phase: a retrospective analysis. J Assisted Reprod and Genetics 2018; 35(3):475-482. DOI:10.1007/s10815‒017‒1096-y.
Gebbie AE, Glasier A, Sweeting V. Incidence of ovulation in perimenopausal women before and during Hormone Replacement Therapy. Contraception 1995; 52:221-2 DOI:10.1016/0010‒7824(95)00184-c.
Eldeen, H, Fawzi, H. Postmenopausal pregnancy: is it due to premature ovarian failure, resistant ovarian syndrome or more accurately ovarian dysfunction syndrome? JOG 2003; 23(6):672-673. DOI:10.1080/01443610310001607913.
Di Bella ZI, Bianchi AM, Araujo FF, Sartori MG, Girão MJl. Contraception and family planning at the extreme of reproductive life- climacteric. Rev Asso Med Bras 2016; 62(5):454-7. DOI:10.1590/1806-9282.62.05.454.
Glasier A, Gebbie A. Contraception for the older woman. BCOG 1996; 10:1:121-135. DOI: 10.1016/s0950-3552(96)80066-6.
Allen R, Schreiber CA, Crowley WF, et al. Combined Oestrogen-progestin oral contraceptives: patients selection, counseling and use. UpToDate 2021; 03.
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