Chronic kidney disease and oral health – a review

Kuba Sękowski; Justyna Grudziąż-Sękowska; Agnieszka Osiadło; Ryszard Gelert; Jarosław  Pinkas; Janusz Ostrowski

doi:10.36553/wm.169

Published: 2025-03-28

Vol. 6 No. 2 (2024)

Chronic kidney disease and oral health – a review

Kuba Sękowski , Justyna Grudziąż-Sękowska , Agnieszka Osiadło , Ryszard Gelert , Jarosław Pinkas , Janusz Ostrowski

Wiedza Medyczna

Section: Review papers

https://doi.org/10.36553/wm.169

Abstract

Chronic kidney disease (CKD) and oral diseases are interrelated, especially in hemodialysis patients who are more susceptible to infections, periodontal diseases, and other dental issues. The increased risk of these conditions is due to metabolic disturbances, dry mouth, immune dysfunction, and side effects of treatment. Periodontal disease negatively impacts CKD management and increases cardiovascular risk. Therefore, the inclusion of prevention, diagnosis, and treatment of oral diseases in the treatment plan for CKD patients is essential to improving quality of life and treatment outcomes.

Keywords:

periodontal disease, hemodialysis, dialysis therapy, caries, chronic renal failure

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Sękowski, K., Grudziąż-Sękowska, J., Osiadło, A., Gelert, R., Pinkas, J. ., & Ostrowski, J. (2025). Chronic kidney disease and oral health – a review. Wiedza Medyczna, 6(2), 1–6. https://doi.org/10.36553/wm.169

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References

(1) Bayraktar G, Kazancioglu R, Bozfakioglu S, et al. Stimulated salivary flow rate in chronic hemodialysis patients. Nephron 2002; 91:210-4. DOI:10.1159/000058394.
Google Scholar

(2) Craig RG, Spittle MA, Levin NW. Importance of periodontal disease in the kidney patient. Blood Purif 2002; 20:113-9. DOI:10.1159/000046994.
Google Scholar

(3) Frankenthal S, Nakhoul F, Machtei EE, et al. The effect of secondary hyperparathyroidism and hemodialysis therapy on alveolar bone and periodontium. J Clin Periodontol 2002; 29:479-83. DOI:10.1034/j.1600-051x.2002.290601.x.
Google Scholar

(4) Grau AJ, Buggle F, Ziegler C, et al. Association between acute cerebrovascular ischemia and chronic and recurrent infection. Stroke 1997; 28:1724-1729. DOI:10.1161/01.
Google Scholar

(5) Gavaldá C, Bagán JV, Scully C, et al. Renal hemodialysis patients: oral, salivary, dental and periodontal findings in 105 adult cases. Oral Diseases 1999; 5:299-302. DOI:10.1111/j.1601-0825.1999.tb00093.x.
Google Scholar

(6) Proctor R, Kumar N, Stein A. et al. Oral and dental aspects of chronic renal failure. J Dent Res 2005; 84:199-208. DOI:10.
Google Scholar

/154405910508400301.
Google Scholar

(7) Leão JC, Gueiros LA, Segundo AV, et al. Uremic stomatitis in chronic renal failure. Clinics (Sao Paulo) 2005 J; 60(3):259-262. DOI:10.1590/s1807-59322005000300013.
Google Scholar

(8) Sudarshan R, Annigeri RG, Mamatha GP et al. Uremic stomatitis. Contemp Clin Dent 2012; 3(1):113-115. DOI:10.4103/
Google Scholar

-237X.94560.
Google Scholar

(9) Souza PRM, Mosena G, Dantas ML, et al. Uremic stomatitis. Anais Brasileiros de Dermatologia; 97(3):404-405.
Google Scholar

(10) Hasselfeld K, Van Ingen K, Chandler G, et al. White Tongue Because of Uremic Stomatitis as a Sign of Advanced Kidney Disease. Pediatrics October 2022; 150(4):e2021056023. DOI:10.1542/peds.2021-056023.
Google Scholar

(11) Małyszko J, Sierakowski S, Kita K, et al. Diagnostyka i klinika zaburzeń metabolizmu kostnego w przewlekłej niewydolności nerek. Nowa Med-Osteop 2004, 3:163-172.
Google Scholar

(12) Sokołowska-Trelka A, Grzebieluch W, Dubiński B: Problemy stomatologiczne u chorych na schyłkową niewydolność nerek. Dent Med Probl 2005; 42:351-356.
Google Scholar

(13) Borawski J, Wilczyńska-Borawska M, Stokowska W, et al. The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients. Nephrol Dial Transplant 2007; 22:457-464. DOI:10.1093/ndt/gfl676.
Google Scholar

(14) Löcsey L, Alberth M, Mauks G. Dental management of chronic hemodialysis patients. Int Urol Nephrol 1986; 18:211-213. DOI:10.1007/BF02082610.
Google Scholar

(15) Naugle K, Darby ML, Bauman DB, et al. The oral health status of individuals on renal dialysis. Ann Periodontol 1998; 3:197--205. DOI:10.1902/annals.1998.3.1.197.
Google Scholar

(16) Serafin J, Marino S, Carmona I, et al. Oral health status in patients with moderate-severe and terminal renal failure. Oral Med Oral Patol Oral Chir Bucal 2007; 12:305-310.
Google Scholar

(17) Borawski J, Wilczyńska-Borawska M, Stokowska, et al. The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients. Nephrol Dial Transplant 2007; 22:457-464. DOI:10.1093/ndt/gfl676.
Google Scholar

(18) Wilczyńska-Borawska M, Borawski J, Stokowska W. Risk factors of tooth loss in maintenance hemodialysis patients. Dent Med Probl 2004; 41:751-756.
Google Scholar

(19) Boutsi EA, Paikos S, Dafni UG, et al. Dental and periodontal status of Sjőgren's syndrome. J Clin Periodontol 2000; 27:231--235. DOI:10.1034/j.1600-051x.2000.027004231.x.
Google Scholar

(20) Featherstone JD. The continuum of dental caries-evidence for a dynamic disease process. J Dent Res 2004; 83:39-42. DOI:10.1177/154405910408301s08.
Google Scholar

(21) Obry F, Belcourt AB, Frank R. Low caries activity and salivary pH in youngers dialyzed for chronic renal failure. J Biol Buccale 1984; 12:181-186.
Google Scholar

(22) Obry F, Belcourt AB, Frank R, et al. Biochemical study of whole saliva from children with chronic renal failure. ASDC J Dent Child 1987; 54:429-432.
Google Scholar

(23) Rojas Peńa S, Mora Muńoz A, Gordillo Paniagua G, et al. Indice CPO en pacientes con enfermedad renal terminal [DMF index in patients with end-stage kidney disease]. Pract Odontol 1991; 12:9-11.
Google Scholar

(24) Kalender B, Ozdemir AC, Dervisoglu E, et al.: Quality of life in chronic kidney disease: effects of treatment modality, depression. Malnutrition and inflammation. Int J Clin Pract 2007; 61:569-576. DOI:10.1111/j.1742-1241.2006.01251.x.
Google Scholar

(25) World Health Organization Oral Health Surveys-Basic methods. Geneva 1997. WHO Oral Health Country/Area Profile Program.
Google Scholar

(26) Kalender B, Ozdemir AC, Korolu G. Association of depresion with markers of nutrition and inflammation in chronic kidney disease and end-stage renal disease. Nephrol Clin Pract 2006; 102:115-121. DOI:10.1159/000089669.
Google Scholar

(27) Mak RH, DeFronzo RA. Glucose and insulin metabolism in uremia. Nephron 1992; 61(4):377-382. DOI:10.1159/000186953.
Google Scholar

(28) Excerpts from the USRDS 2009 annual data report: Atlas of endstage renal disease in the United States. United States Renal Data System. Am J Kidney Dis 2010; 55(Suppl. 1):S1. DOI:10.1053/j.ajkd.2009.10.009.
Google Scholar

(29) Schmidt MI, Duncan BB, Sharrett AR, et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999; 353(9165):1649-1652. DOI:10.1016/s0140-6736(99)01046-6.
Google Scholar

(30) Lalla E, Lamster IB, Drury S, et al. Hyperglycemia, glycoxidation and receptor for advanced glycation endproducts: potential mechanisms underlying diabetic complications, including diabetes-associated periodontitis. Periodontol 2000; 23:50-62. DOI:10.1034/j.1600-0757.2000.2230104.x.
Google Scholar

(31) Enblad E, Lundin S, Sjodin B, et al. Caries and salivary status in young adults with type 1 diabetes. Swed Dent J 2001; 25:53-60.
Google Scholar

(32) Knecht MC, Syrjala AM, Laukkanen P, et al. Self-efficacy as a common variable in oral health behaviour and diabetes adherence. Eur J Oral Sci 1999; 107:89-96. DOI:10.1046/j.0909-8836.1999.eos107203.x.
Google Scholar

(33) Löe H. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care 1993; 16:329-334.
Google Scholar

(34) Guneri P, Unlu F, Yeslibek B, et al. Vascular endothelial growth factor in gingival tissues and crevicular fluids of diabetic and healthy periodontal patients. J Periodontol 2004; 75:91-97. DOI:10.1902/jop.2004.75.1.91.
Google Scholar

(35) Mahabadi J, Meyle J. Cukrzyca a zapalenie przyzębia. Quintessence Periodont – Implanty 2006; 3:179-188.
Google Scholar

(36) Craig R, Yip J, So M, et al. Relationship of destructive periodontal disease to the acute phase response. J. Periodontol 2003, 74:1007-1016. DOI:10.1902/jop.2003.74.7.1007.
Google Scholar

(37) Kadiroglu K, Kadiroglu E, Sit D, et al. Periodontitis is an important and occult source of inflammation in hemodialysis patients. Blood Purif 2006; 24:400-404. DOI:10.1159/000093683.
Google Scholar

(38) Cengiz M, Bal S, Gokcay S, et al. Does periodontal disease reflect atherosclerosis in continuos ambulatory peritoneal dialysis patients? J. Periodontol 2007; 78:1926-1934. DOI:10.1902/jop.2007.060499.
Google Scholar

(39) Zimmermann J, Herrlinger S, Pruy A, et al. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 1999; 55:648-658. DOI:10.1046/j.1523-1755.1999.00273.x.
Google Scholar